认知神经生物学
神经行为学
神经联结组组学

   

071006-神经生物学

利用果蝇研究学习记忆、睡眠等高级脑功能特征及其神经环路基础

   

1965年毕业于莫斯科大学生物物理学专业
1979年获慕尼黑大学自然科学博士学位

1988—中科院生物物理所研究所研究员
1999—中国科学院神经科学研究所高级研究员
1982.11.30—1984.06.30德国马普学会生物控制论研究所访问学者
1984—1991中科院生物物理研究所视觉信息加工研究室主任
1991—1995中科院生物物理所研究所神经生物学室主任
1999.11—中国科学院神经科学研究所学习记忆实验室高级研究员
2005— 脑与认知科学国家重点实验室学术委员会主任

2003—2008中国科学院神经科学研究所副所长
1999—2001亚太IBRO理事
2001— Editorial board Journal of Integrative neuroscience;
2008— Associate Editors of BMC Neuroscience
2003年当选为中国科学院院士

2006年获何梁何利基金会科学与技术进步奖；
2008年度亚太神经网络协会杰出成就奖。

1.Liu, H., Zhou, B., Yan, W., Lei, Z., Zhao, X., Zhang, K., and Guo, A. (2014) Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila. Eur. J. Neurosci. 40: 2744-2754.
2.Lei, Z., Chen, K., Li, H., Liu, H., and Guo, A.(2013) The GABA system regulates the sparse coding of odors in the mushroom bodies of Drosophila. Biochem. Biophys. Res. Commun. 436: 35-40.
3.Li, H., Li, Y., Lei, Z., Wang, K., and Guo, A. (2013) Transformation of odor selectivity from projection neurons to single mushroom body neurons mapped with dual-color calcium imaging. Proc. Natl. Acad. Sci. USA. 110: 12084-12089.
4.Yang, X., and Guo, A. (2013) Distinct acute zones for visual stimuli in different visual tasks in Drosophila. PLoS One 8: e61313.
5.Wu, Y., Ren, Q., Li, H., and Guo, A. (2012) The GABAergic anterior paired lateral neurons facilitate olfactory reversal learning in Drosophila. Learn. Mem. 19: 478-486.
6.Ren, Q., Li, H., Wu, Y., Ren, J., and Guo, A.（2012）A gabaergic inhibitory neural circuit regulates visual reversal learning in drosophila. J. Neurosci. 32:11524 –11538
7.Chen, B., Liu, H., Ren, J., and Guo, A. (2012) Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior. Biochem Biophys Res Commun. 423: 557-563.
8. Li, X., Yu, F., and Guo, A. (2009) Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila. Sleep 32: 1417-1424.
9. Liu, T., Dartevelle, L., Yuan, C., Wei, H., Wang, Y., Ferveur, J, and Guo, A. (2009) Reduction of dopamine level enhances the attractiveness of male Drosophila to other males. PLoS ONE 4: e4574.
10. Lu, S., Fang, J., Guo, A., and Peng, Y. (2009) Impact of network topology on decision-making. Neural Netw. 22: 30-40.
11. Liu, T., Dartevelle, L., Yuan, C., Wei, H., Wang, Y., Ferveur J., and Guo, A. (2008) Increased dopamine level enhances male-male courtship in Drosophila. J. Neurosci. 28: 5539-5546.
12. Xi, W., Peng, Y., Guo, J., Ye, Y., Zhang, K., Yu, F., and Guo, A. (2008) Mushroom bodies modulate salience-based selective fixation behavior in Drosophila. Eur. J. Neurosci., 27: 1441-1451.
13. Zhang, K., Guo, J., Peng, Y., Xi, W., and Guo, A. (2007) Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila. Science 316: 1901-1904.
14. Peng, Y., Xi, W., Zhang, W., Zhang, K., and Guo, A. (2007) Experience Improves Feature Extraction in Drosophila. J. Neurosci. 27: 5139-5145.
15. Xu, S., Cang, C., Liu, X., Peng, Y., Ye, Y., Zhao, Z., and Guo, A. (2006) Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav. 5(8): 602-613.
16. Guo, J., and Guo, A. (2005) Crossmodal Interactions Between Olfactory and Visual Learning in Drosophila. Science 309: 307-310.
17. Zhou, X., Yuan, C., and Guo, A. (2005) Drosophila Olfactory Response Rhythms Require Clock Genes but Not Pigment Dispersing Factor or Lateral Neurons. J. Biol. Rhythm. 20: 237-244.
18. Ye, Y., Xi, W., Peng, Y., Wang, Y., and Guo, A. (2004) Long-term but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. Eur. J. Neurosci. 20: 1001-1007.
19. Tang, S., and Guo, A. (2001) Choice behavior of Drosophila facing contradictory visual cues. Science, 294: 1543-1547.

（1） 脑功能联结图谱计划（中国科学院战略性先导科技专项），主持，2012 - 2016
（2）个体抉择与群体抉择的神经生物学基础（基金委重点项目），主持，2011-12--2015-12
（2） 智力的神经基础（973），参与，2011-07--2015-07